MP28-11 ANNEXIN A1 INHIBITS NLRP3 AND PREVENTS INFLAMMATION DURING BLADDER OUTLET OBSTRUCTION

AB298. SPR-25 NLRP3/IL-1β mediates denervation during bladder outlet obstruction in rats

AIMS Denervation of the bladder is a detrimental consequence of bladder outlet obstruction (BOO). We have previously shown that, during BOO, inflammation triggered by the NLRP3 inflammasome in the urothelia mediates physiological bladder dysfunction and downstream fibrosis in rats. The aim of this study was to assess the effect of NLRP3-mediated inflammation on bladder denervation during BOO. ...

Protection of Neurons from Denervation Prevents Bladder Dysfunction following Bladder Outlet Obstruction in Rat

Bladder outlet obstruction due to labial agglutination.

Here, we report the case of a 63-year-old female patient who presented with emptying symptoms and was subsequently diagnosed with delayed labial agglutination. The adhered labia minora were divided by blunt dissection, and a topical estrogen ointment was applied after surgery. The patient's voiding symptoms were completely resolved and no recurrence of labial agglutination was noted 3 months af...

Female Urethral Condyloma Causing Bladder Outlet Obstruction

In women, urethral condyloma rarely leads to a bladder outlet obstruction. A 39-year-old woman who presented with frequency, urgency, and residual urine sensation was found to have a condyloma in her urethral meatus. Urodynamic study indicated bladder outlet obstruction. After condyloma excision, she returned to normal voiding, and the free maximum flow rate improved. In women, excision of uret...

Urethra duplication with bladder outlet membrane obstruction

A two-year-old boy presented with voiding through two orifices, with one greater than the other. On physical examination, he had bifid glans penis with a complete foreskin and no other anomaly (Figure 1). The urinalysis and urine culture were normal. It is difficult to find the internal opening of the urethra by cystoscopy through cystostomy. Catheterization through the external openings of the...